Host Factors Influencing the Behavior of Subcutaneous Sarcomas Induced by 3,4,9,10-dibenzpyrene in C57bl-6 Mice.
نویسندگان
چکیده
dibenzpyrene-induced subcutaneous sarcomas and their transplants to various chemotherapeutic agents were described (5). This report deals with intrinsic factors such as sex, age, nutritional status, and connective-tissue reactivity which determine the rate of formation and subsequent behavior of such tumors in the untreated hosts, and with studies on the fate of the carcinogen, large amounts of which, in contrast to other polycyclic hydro carbons, remain at the injection site and are de monstrable in the tumors.
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C57BL/6 mice given subcutaneous injections of a tumor-producing dose of 3,4,9,10dibenzpyrene were subjected to either skin wounding or laparotomy. Tumors were induced earlier and progressed more rapidly in the mice subjected to either of the surgical procedures. The mice subjected to laparotomy exhibited the greatest effect of tumorigenesis compared with that in control and skin-wounded mice. T...
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ورودعنوان ژورنال:
- Cancer research
دوره 23 شماره
صفحات -
تاریخ انتشار 1963